Sirolimus-Embedded Silk Microneedle Wrap to Prevent Neointimal Hyperplasia in Vein Graft Model

Sirolimus-Embedded Silk Microneedle Wrap to Prevent Neointimal Hyperplasia in Vein Graft Model

We investigated the role of a sirolimus-embedded silk microneedle (MN) wrap as an external vascular device for drug delivery efficacy, inhibition of neointimal hyperplasia, and vascular remodeling. Using dogs, a vein graft model was developed to interpose the carotid or femoral artery with the jugul...

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Bibliographic Details
Main Authors: Jung-Hwan Kim, Eui Hwa Jang, Ji-Yeon Ryu, Jiyong Lee, Jae Ho Kim, Wonhyoung Ryu, Young-Nam Youn
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
neointimal hyperplasia
vein graft
microneedle
silk fibroin
perivascular drug delivery
vascular wraps
Online Access:https://www.mdpi.com/1422-0067/24/4/3306

Internet

https://www.mdpi.com/1422-0067/24/4/3306

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