The impacts of CYP3A4 genetic polymorphism and drug interactions on the metabolism of lurasidone

The impacts of CYP3A4 genetic polymorphism and drug interactions on the metabolism of lurasidone

The aim of this study was to investigate the impacts of 24 variants of recombinant human CYP3A4 and drug interactions on the metabolism of lurasidone. In vitro, enzymatic reaction incubation system of CYP3A4 was established to determine the kinetic parameters of lurasidone catalyzed by 24 CYP3A4 var...

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Bibliographic Details
Main Authors: Qingqing Li, Jing Wang, Zheng-lu Wang, Yuxin Shen, Qi Zhou, Ya-nan Liu, Guo-xin Hu, Jian-ping Cai, Ren-ai Xu
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Lurasidone
CYP3A4 genetic polymorphism
Olmutinib
Interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016311

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http://www.sciencedirect.com/science/article/pii/S0753332223016311

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