DOWNREGULATION OF STEAROYL-COA DESATURASE 1 (SCD-1) PROMOTES RESISTANCE TO IMATINIB IN CHRONIC MYELOID LEUKEMIA

DOWNREGULATION OF STEAROYL-COA DESATURASE 1 (SCD-1) PROMOTES RESISTANCE TO IMATINIB IN CHRONIC MYELOID LEUKEMIA

Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disease resulting in the fusion of BCR and ABL genes and characterized by the presence of the reciprocal translocation t(9;22)(q34;q11). BCR-ABL, a product of the BCR-ABL fusion gene, is a structurally active tyrosine kinase and...

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Bibliographic Details
Main Authors: Buket Altinok Gunes, Yalda Hekmatshoar, Tulin Ozkan, Sureyya Bozkurt, O.Sena Aydos, Yahya Buyukasik, Elifcan Aladag, Asuman Sunguroglu
Format: Article
Language:English
Published: PAGEPress Publications 2023-01-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
CML
Imatinib resistance
BCR-ABL mutations
sCD-1
Online Access:http://www.mjhid.org/index.php/mjhid/article/view/5171

Internet

http://www.mjhid.org/index.php/mjhid/article/view/5171

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