Cocaine-Induced DNA-Dependent Protein Kinase Relieves RNAP II Pausing by Promoting TRIM28 Phosphorylation and RNAP II Hyperphosphorylation to Enhance HIV Transcription

Cocaine-Induced DNA-Dependent Protein Kinase Relieves RNAP II Pausing by Promoting TRIM28 Phosphorylation and RNAP II Hyperphosphorylation to Enhance HIV Transcription

Drug abuse continues to pose a significant challenge in HIV control efforts. In our investigation, we discovered that cocaine not only upregulates the expression of the DNA-dependent protein kinase (DNA-PK) but also augments DNA-PK activation by enhancing its phosphorylation at S2056. Moreover, DNA-...

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Bibliographic Details
Main Authors: Adhikarimayum Lakhikumar Sharma, Priya Tyagi, Meenata Khumallambam, Mudit Tyagi
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
cocaine
DNA-PK
HIV transcription
HIV gene expression
replication
RNA polymerase
Online Access:https://www.mdpi.com/2073-4409/13/23/1950

Internet

https://www.mdpi.com/2073-4409/13/23/1950

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