6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

Here we report on the synthesis, biophysical properties and molecular modeling of oligonucleotides containing unsaturated 6’-fluoro[4.3.0]bicyclo nucleotides (6’F-bc4,3-DNA). Two 6’F-bc4,3 phosphoramidite building blocks (T and C) were synthesized starting from a previously described [3.3.0]bicyclic...

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Bibliographic Details
Main Authors: Sibylle Frei, Andrei Istrate, Christian J. Leumann
Format: Article
Language:English
Published: Beilstein-Institut 2018-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
DNA/RNA affinity
fluorinated cyclopropanes
fluorinated nucleic acids
molecular dynamics simulations
sugar modified nucleosides
Online Access:https://doi.org/10.3762/bjoc.14.288

Internet

https://doi.org/10.3762/bjoc.14.288

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