Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. ‘Diversity Outbred in Australia (DOz)’ is a population of genetically unique mice with profound metabolic heterogeneity. We leveraged this variance...

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Bibliographic Details
Main Authors: Stewart WC Masson, Søren Madsen, Kristen C Cooke, Meg Potter, Alexis Diaz Vegas, Luke Carroll, Senthil Thillainadesan, Harry B Cutler, Ken R Walder, Gregory J Cooney, Grant Morahan, Jacqueline Stöckli, David E James
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
skeletal muscle
insulin resistance
Diversity Outbred
thiostrepton
drug repurposing
Online Access:https://elifesciences.org/articles/86961

Internet

https://elifesciences.org/articles/86961

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