PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism

PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism

BackgroundMalignant melanoma is the most lethal form of skin cancer which shows BRAF mutation in 50% of patients. In this context, the identification of BRAFV600E mutation led to the development of specific inhibitors like PLX4032. Nevertheless, although its initial success, its clinical efficacy is...

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Bibliographic Details
Main Authors: Ombretta Garbarino, Giulia Elda Valenti, Lorenzo Monteleone, Gabriella Pietra, Maria Cristina Mingari, Andrea Benzi, Santina Bruzzone, Silvia Ravera, Riccardo Leardi, Emanuele Farinini, Stefania Vernazza, Melania Grottoli, Barbara Marengo, Cinzia Domenicotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
melanoma
BRAF
PLX4032
targeted therapy resistance
pyruvate dehydrogenase
glutathione
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1210130/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1210130/full

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