The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice

The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice

Identification of fluorescent dyes that label filamentous protein aggregates characteristic of neurodegenerative disease, such as β-amyloid and tau in Alzheimer’s disease (AD), in a live cell culture system has previously been a major hurdle. Here we show that pentameric formyl thiophene acetic acid...

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Bibliographic Details
Main Authors: Aviva eTolkovsky, Jack eBrelstaff, Bernardino eOssola, Jonas eNeher, Therese eKlingstedt, Peter eNilsson, Michel eGoedert, Maria Grazia eSpillantini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Neuroscience
Subjects:
Neurofibrillary Tangles
Alzheimer’s disease
Frontotemporal dementia (FTD)
Hyperphosphorylated tau
Dorsal root ganglion neurons
transgenic P301S tau mouse
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00184/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00184/full

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