Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling

Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling

Cell division cycle 6 (CDC6), an androgen receptor (AR) target gene, is implicated in regulating DNA replication and checkpoint mechanisms. CDC6 expression is increased during prostate cancer (PCa) progression and positively correlates with AR in PCa tissues. AR or CDC6 knockdown, together with AZD7...

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Bibliographic Details
Main Authors: Styliani Karanika, Theodoros Karantanos, Likun Li, Jianxiang Wang, Sanghee Park, Guang Yang, Xuemei Zuo, Jian H. Song, Sankar N. Maity, Ganiraju C. Manyam, Bradley Broom, Ana M. Aparicio, Gary E. Gallick, Patricia Troncoso, Paul G. Corn, Nora Navone, Wei Zhang, Shuhua Li, Timothy C. Thompson
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
androgen receptor
CDC6
Chk1
ATR
TOPBP1
DNA damage
prostate cancer
enzalutamide
AZD7762
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301420

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http://www.sciencedirect.com/science/article/pii/S2211124717301420

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