Pharmacokinetics of a microdosed cocktail of three direct oral anticoagulants in children with congenital heart defects: study protocol for a single-centre clinical trial (DOAC-Child)

Introduction Direct oral anticoagulants (DOACs) are direct inhibitors of coagulation factor Xa and are frequently used in adults for different indications such as deep vein thrombosis or non-valvular atrial fibrillation. Paediatric patients might benefit as well from DOACs because the simplicity and...

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Bibliographic Details
Main Authors: Matthias Gorenflo, Victoria C. Ziesenitz, Gerd Mikus, Simon A Hermann, Kristine Chobanyan-Jürgens
Format: Article
Language:English
Published: BMJ Publishing Group 2023-12-01
Series:BMJ Paediatrics Open
Online Access:https://bmjpaedsopen.bmj.com/content/7/1/e001662.full