FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues.

FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues.

The mitochondrial enzyme 25-hydroxyvitamin D 1α-hydroxylase, which is encoded by the CYP27B1 gene, converts 25OHD to the biological active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). Renal 1α-hydroxylase activity is the principal determinant of the circulating 1,25(OH)2D concentration a...

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Bibliographic Details
Main Authors: Ankanee Chanakul, Martin Y H Zhang, Andrew Louw, Harvey J Armbrecht, Walter L Miller, Anthony A Portale, Farzana Perwad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3760837?pdf=render

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http://europepmc.org/articles/PMC3760837?pdf=render

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