Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel

Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel

Synergistic impairment of the blood-brain barrier (BBB) induced by methamphetamine (METH) and HIV-Tat protein increases the risk of HIV-associated neurocognitive disorders (HAND) in HIV-positive METH abusers. Studies have shown that oxidative stress plays a vital role in METH- and HIV-Tat-induced da...

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Bibliographic Details
Main Authors: Jian Huang, Ruilin Zhang, Shangwen Wang, Dongxian Zhang, Chi-Kwan Leung, Genmeng Yang, Yuanyuan Li, Liu Liu, Yue Xu, Shucheng Lin, Chan Wang, Xiaofeng Zeng, Juan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
transient receptor potential melastatin 2 channel
methamphetamine
HIV-tat protein
blood-brain barrier
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.619436/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.619436/full

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