New RAD51 Inhibitors to Target Homologous Recombination in Human Cells

Targeting DNA repair proteins with small-molecule inhibitors became a proven anti-cancer strategy. Previously, we identified an inhibitor of a major protein of homologous recombination (HR) RAD51, named B02. B02 inhibited HR in human cells and sensitized them to chemotherapeutic drugs <i>in vi...

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Bibliographic Details
Main Authors: Irina S. Shkundina, Alexander A. Gall, Alexej Dick, Simon Cocklin, Alexander V. Mazin
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/12/6/920