O-24 PIRFENIDONE PREVENTS NEOPLASTIC LESIONS DEVELOPMENT BY OXIDATIVE, FIBROGENIC, ANTIPROLIFERATIVE AND EPIGENETIC MECHANISMS REGULATION IN A MODEL OF CHEMICAL HEPATOCARCINOGENESIS
Introduction and Objectives: Hepatocellular carcinoma (HCC) is the most frequent hepatic neoplasia, where oxidative, fibrogenic, proliferative, and epigenetic processes are altered. Pirfenidone (PFD) has been shown to have important hepatoprotective properties. However, its efficacy in HCC developme...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268123001382 |