Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

Beta-catenin (i.e., canonical Wnt) signaling controls CNS angiogenesis and the blood-brain and blood-retina barriers. To explore the role of the Discs large/membrane-associated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin signaling, we studied vascular endothelial cell...

Full description

Bibliographic Details
Main Authors:	Chris Cho, Yanshu Wang, Philip M Smallwood, John Williams, Jeremy Nathans
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-05-01
Series:	eLife
Subjects:	vascular endothelial cells canonical Wnt signaling mouse genetics retinal angiogenesis blood-brain barrier blood-retina barrier
Online Access:	https://elifesciences.org/articles/45542

Similar Items

Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development
by: Chris Cho, et al.
Published: (2019-06-01)

Brain and Retinal Organoids for Disease Modeling: The Importance of In Vitro Blood–Brain and Retinal Barriers Studies
by: Ilenia Martinelli, et al.
Published: (2022-03-01)

Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation
by: Despina Kokona, et al.
Published: (2018-12-01)

Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction
by: Amany Tawfik, et al.
Published: (2020-07-01)

Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures
by: Yanshu Wang, et al.
Published: (2019-04-01)

Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice
by: Casey-Tyler Berezin, et al.
Published: (2023-06-01)

IL-17A Damages the Blood–Retinal Barrier through Activating the Janus Kinase 1 Pathway
by: Eimear M. Byrne, et al.
Published: (2021-07-01)

<it>In vivo</it> assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish
by: Watanabe Kohei, et al.
Published: (2012-08-01)

Evaluating Ocular Response in the Retina and Optic Nerve Head after Single and Fractionated High-Energy Protons
by: Xiao-Wen Mao, et al.
Published: (2021-08-01)

Retinal and Cortical Blood Flow Dynamics Following Systemic Blood-Neural Barrier Disruption
by: Flora Hui, et al.
Published: (2017-10-01)

Brain and Retinal Pericytes: Origin, Function and Role
by: Andrea eTrost, et al.
Published: (2016-02-01)

Comprehensive Evidence of Carrier-Mediated Distribution of Amantadine to the Retina across the Blood–Retinal Barrier in Rats
by: Yusuke Shinozaki, et al.
Published: (2021-08-01)

Upregulated inflammatory associated factors and blood-retinal barrier changes in the retina of type 2 diabetes mellitus model
by: Rui-Jin Ran, et al.
Published: (2016-11-01)

Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy
by: Xuefei Fu, et al.
Published: (2023-01-01)

Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity
by: Gokce Gurler, et al.
Published: (2023-06-01)

Assessment of Inner Blood–Retinal Barrier: Animal Models and Methods
by: Kiran Bora, et al.
Published: (2023-10-01)

The retinal pigment epithelium: Functions and roles in ocular diseases
by: Shasha Wang, et al.
Published: (2024-11-01)

Evans blue staining to detect deep blood vessels in peripheral retina for observing retinal pathology in early-stage diabetic rats
by: Kang-Pei Shi, et al.
Published: (2021-10-01)

TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling
by: Maria B. Lai, et al.
Published: (2017-06-01)

Effect of pyridone agent on blood-retinal barrier in diabetic mice
by: Si-Qi Xiong, et al.
Published: (2017-06-01)

Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis
by: Nicole El-Darzi, et al.
Published: (2021-10-01)

A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
by: Rony Chidiac, et al.
Published: (2021-06-01)

Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS
by: Andreia Goncalves, et al.
Published: (2022-11-01)

Imaging single-cell blood flow in the smallest to largest vessels in the living retina
by: Aby Joseph, et al.
Published: (2019-05-01)

Endothelial β-Catenin Deficiency Causes Blood-Brain Barrier Breakdown via Enhancing the Paracellular and Transcellular Permeability
by: Basharat Hussain, et al.
Published: (2022-05-01)

Knockdown of fibrillin-1 suppresses retina-blood barrier dysfunction by inhibiting vascular endothelial apoptosis under diabetic conditions
by: Yue Zhang, et al.
Published: (2024-08-01)

The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema
by: Esmeralda K. Bosma, et al.
Published: (2018-09-01)

Corrigendum: Endothelial β-catenin deficiency causes blood-brain barrier breakdown via enhancing the paracellular and transcellular permeability
by: Basharat Hussain, et al.
Published: (2024-04-01)

Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier
by: Sneha Singh, et al.
Published: (2018-09-01)

Substance Delivery across the Blood-Brain Barrier or the Blood-Retinal Barrier Using Organic Cation Transporter Novel Type 2 (OCTN2)
by: Toshihiko Tashima
Published: (2024-08-01)

Unveiling the hidden connection: the blood-brain barrier’s role in epilepsy
by: Jinkun Han, et al.
Published: (2024-08-01)

Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation
by: Ahmed M. Abu El-Asrar, et al.
Published: (2022-01-01)

A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture
by: Mark F Sabbagh, et al.
Published: (2020-01-01)

Vitamin D3 preserves blood retinal barrier integrity in an in vitro model of diabetic retinopathy
by: Francesca Lazzara, et al.
Published: (2022-08-01)

[Peculiarities of normal retinal blood supply from the side of retinal pool]
by: Paltov E.V.
Published: (2015-06-01)

The Structural Characteristics of Compounds Interacting with the Amantadine-Sensitive Drug Transport System at the Inner Blood–Retinal Barrier
by: Yusuke Shinozaki, et al.
Published: (2023-03-01)

Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes1
by: Dongxu Fu, et al.
Published: (2014-05-01)

Uptake Study in Lysosome-Enriched Fraction: Critical Involvement of Lysosomal Trapping in Quinacrine Uptake but Not Fluorescence-Labeled Verapamil Transport at Blood-Retinal Barrier
by: Yoshiyuki Kubo, et al.
Published: (2020-08-01)

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
by: Tao-Hsin Chang, et al.
Published: (2015-07-01)

Overexpression of ACE2 ameliorates Aβ‐induced blood–brain barrier damage and angiogenesis by inhibiting NF‐κB/VEGF/VEGFR2 pathway
by: Xueling Zhang, et al.
Published: (2023-06-01)