GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment

GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment

Abstract Background Extravillous trophoblasts (EVTs) are essential cells during the formation of the placenta, with the major function of invading the maternal decidua, anchoring the developing placenta to the uterus, remodeling uterine arteries, and regulating immune responses to prevent rejection....

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Bibliographic Details
Main Authors: Jia Mao, Ying Feng, Yayun Zheng, Yaqiu Gao, Linyu Zhang, Xinrui Sun, Yilun Wu, Xiaofeng Zhu, Fang Ma
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell Communication and Signaling
Subjects:
GPR65
Adhesion
Trophoblast cells
Early pregnancy loss
cAMP-ERK signaling pathway
Online Access:https://doi.org/10.1186/s12964-023-01249-3

Internet

https://doi.org/10.1186/s12964-023-01249-3

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