Epacadostat stabilizes the apo-form of IDO1 and signals a pro-tumorigenic pathway in human ovarian cancer cells

Epacadostat stabilizes the apo-form of IDO1 and signals a pro-tumorigenic pathway in human ovarian cancer cells

The tryptophan-degrading enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is a plastic immune checkpoint molecule that potently orchestrates immune responses within the tumor microenvironment (TME). As a heme-containing protein, IDO1 catalyzes the conversion of the essential amino acid tryptophan into im...

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Bibliographic Details
Main Authors: Sofia Rossini, Sara Ambrosino, Claudia Volpi, Maria Laura Belladonna, Maria Teresa Pallotta, Eleonora Panfili, Chiara Suvieri, Antonio Macchiarulo, Giada Mondanelli, Ciriana Orabona
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
apo-IDO1
non-enzymatic function of IDO1
IDO1 plasticity
IDO1 protein degradation
epacadostat
SKOV-3 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1346686/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1346686/full

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