A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity
Abstract Background Almonds have been shown to lower LDL cholesterol but there is limited information regarding their effects on the dyslipidemia characterized by increased levels of very low density lipoproteins (VLDL) and small, dense low-density lipoprotein (LDL) particles that is associated with...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-04-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-019-1025-4 |
| _version_ | 1811223931434041344 |
|---|---|
| author | Paul T. Williams Nathalie Bergeron Sally Chiu Ronald M. Krauss |
| author_facet | Paul T. Williams Nathalie Bergeron Sally Chiu Ronald M. Krauss |
| author_sort | Paul T. Williams |
| collection | DOAJ |
| description | Abstract Background Almonds have been shown to lower LDL cholesterol but there is limited information regarding their effects on the dyslipidemia characterized by increased levels of very low density lipoproteins (VLDL) and small, dense low-density lipoprotein (LDL) particles that is associated with abdominal adiposity and high carbohydrate intake. The objective of the present study was to test whether substitution of almonds for other foods attenuates carbohydrate-induced increases in small, dense LDL in individuals with increased abdominal adiposity. Methods This was a randomized cross-over study of three 3wk diets, separated by 2wk washouts: a higher-carbohydrate (CHO) reference diet (CHOhigh), a higher-CHO diet with isocaloric substitution of 20% kcal (E) from almonds (CHOhigh + almonds), and a lower-CHO reference diet (CHOlow) in 9 men and 15 women who were overweight or obese. The two CHOhigh diets contained 50% carbohydrate, 15% protein, 35% fat (6% saturated, 21% monounsaturated, 8% polyunsaturated), while the CHOlow diet contained 25% carbohydrate, 28% protein, 47% fat (8% saturated, 28% monounsaturated, 8% polyunsaturated). Lipoprotein subfraction concentrations were measured by ion mobility. Results Relative to the CHOlow diet: 1) the CHOhigh + almonds diet significantly increased small, dense LDLIIIa (mean difference ± SE: 28.6 ± 10.4 nmol/L, P = 0.008), and reduced LDL-peak diameter (− 1.7 ± 0.6 Å, P = 0.008); 2) the CHOhigh diet significantly increased medium-sized LDLIIb (24.8 ± 11.4 nmol/L, P = 0.04) and large VLDL (3.7 ± 1.8 nmol/L, P = 0.05). Relative to CHOlow, the effects of CHOhigh on LDLIIIa (17.7 ± 10.6 nmol/L) and LDL-peak diameter (− 1.1 ± 0.6 Å) were consistent with those of CHOhigh + almonds, and the effects of CHOhigh + almonds on LDLIIb (21.0 ± 11.2 nmol/L) and large VLDL (2.8 ± 1.8 nmol/L) were consistent with those of CHOhigh, but did not achieve statistical significance (P > 0.05). None of the variables examined showed a significant difference between the CHOhigh + almonds and CHOhigh diets (P > 0.05). Conclusion Our analyses provided no evidence that deriving 20% E from almonds significantly modifies increases in levels of small, dense LDL or other plasma lipoprotein changes induced by a higher carbohydrate low saturated fat diet in individuals with increased abdominal adiposity. Trial registration Clinicaltrials.gov NCT01792648. |
| first_indexed | 2024-04-12T08:42:04Z |
| format | Article |
| id | doaj.art-b8de51e04bcf4873956d5ccaafb9a50f |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-12T08:42:04Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-b8de51e04bcf4873956d5ccaafb9a50f2022-12-22T03:39:51ZengBMCLipids in Health and Disease1476-511X2019-04-011811910.1186/s12944-019-1025-4A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposityPaul T. Williams0Nathalie Bergeron1Sally Chiu2Ronald M. Krauss3Children’s Hospital Oakland Research InstituteChildren’s Hospital Oakland Research InstituteChildren’s Hospital Oakland Research InstituteChildren’s Hospital Oakland Research InstituteAbstract Background Almonds have been shown to lower LDL cholesterol but there is limited information regarding their effects on the dyslipidemia characterized by increased levels of very low density lipoproteins (VLDL) and small, dense low-density lipoprotein (LDL) particles that is associated with abdominal adiposity and high carbohydrate intake. The objective of the present study was to test whether substitution of almonds for other foods attenuates carbohydrate-induced increases in small, dense LDL in individuals with increased abdominal adiposity. Methods This was a randomized cross-over study of three 3wk diets, separated by 2wk washouts: a higher-carbohydrate (CHO) reference diet (CHOhigh), a higher-CHO diet with isocaloric substitution of 20% kcal (E) from almonds (CHOhigh + almonds), and a lower-CHO reference diet (CHOlow) in 9 men and 15 women who were overweight or obese. The two CHOhigh diets contained 50% carbohydrate, 15% protein, 35% fat (6% saturated, 21% monounsaturated, 8% polyunsaturated), while the CHOlow diet contained 25% carbohydrate, 28% protein, 47% fat (8% saturated, 28% monounsaturated, 8% polyunsaturated). Lipoprotein subfraction concentrations were measured by ion mobility. Results Relative to the CHOlow diet: 1) the CHOhigh + almonds diet significantly increased small, dense LDLIIIa (mean difference ± SE: 28.6 ± 10.4 nmol/L, P = 0.008), and reduced LDL-peak diameter (− 1.7 ± 0.6 Å, P = 0.008); 2) the CHOhigh diet significantly increased medium-sized LDLIIb (24.8 ± 11.4 nmol/L, P = 0.04) and large VLDL (3.7 ± 1.8 nmol/L, P = 0.05). Relative to CHOlow, the effects of CHOhigh on LDLIIIa (17.7 ± 10.6 nmol/L) and LDL-peak diameter (− 1.1 ± 0.6 Å) were consistent with those of CHOhigh + almonds, and the effects of CHOhigh + almonds on LDLIIb (21.0 ± 11.2 nmol/L) and large VLDL (2.8 ± 1.8 nmol/L) were consistent with those of CHOhigh, but did not achieve statistical significance (P > 0.05). None of the variables examined showed a significant difference between the CHOhigh + almonds and CHOhigh diets (P > 0.05). Conclusion Our analyses provided no evidence that deriving 20% E from almonds significantly modifies increases in levels of small, dense LDL or other plasma lipoprotein changes induced by a higher carbohydrate low saturated fat diet in individuals with increased abdominal adiposity. Trial registration Clinicaltrials.gov NCT01792648.http://link.springer.com/article/10.1186/s12944-019-1025-4AlmondsTriglyceridesLipidsLipoprotein sizeHigh carbohydrate |
| spellingShingle | Paul T. Williams Nathalie Bergeron Sally Chiu Ronald M. Krauss A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity Lipids in Health and Disease Almonds Triglycerides Lipids Lipoprotein size High carbohydrate |
| title | A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity |
| title_full | A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity |
| title_fullStr | A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity |
| title_full_unstemmed | A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity |
| title_short | A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity |
| title_sort | randomized controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate lower fat diet in men and women with abdominal adiposity |
| topic | Almonds Triglycerides Lipids Lipoprotein size High carbohydrate |
| url | http://link.springer.com/article/10.1186/s12944-019-1025-4 |
| work_keys_str_mv | AT paultwilliams arandomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity AT nathaliebergeron arandomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity AT sallychiu arandomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity AT ronaldmkrauss arandomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity AT paultwilliams randomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity AT nathaliebergeron randomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity AT sallychiu randomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity AT ronaldmkrauss randomizedcontrolledtrialontheeffectsofalmondsonlipoproteinresponsetoahighercarbohydratelowerfatdietinmenandwomenwithabdominaladiposity |