Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease

Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease

Abstract Mesenchymal stromal cells (MSCs) are multipotent adult stem cells which possess immunomodulatory and repair capabilities. In this study, we investigated whether MSC therapy could modulate inflammation and lung damage in the lungs of Scnn1b-transgenic mice overexpressing the β-subunit of the...

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Bibliographic Details
Main Authors: Declan F. Doherty, Lydia E. Roets, Caoifa M. Dougan, Ryan R. Brown, Ian J. Hawthorne, Cecilia O’Kane, Anna D. Krasnodembskaya, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Mesenchymal Stromal Cell
Inflammation
Emphysema
Peroxisome proliferator-activated receptor-γ
Online Access:https://doi.org/10.1038/s41598-024-81276-3

Internet

https://doi.org/10.1038/s41598-024-81276-3

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