Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target

Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear pores is unfeasible, so that a multistage-regulated export pathway through the nuclear lamina and both leaflets of the nuclear membrane has e...

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Bibliographic Details
Main Authors: Julia Tillmanns, Sigrun Häge, Eva Maria Borst, Julia Wardin, Jan Eickhoff, Bert Klebl, Sabrina Wagner, Christina Wangen, Friedrich Hahn, Eileen Socher, Manfred Marschall
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
human cytomegalovirus
regulation of viral replication
nuclear egress complex (NEC)
conditional expression of viral core NEC proteins
antiviral targeting based on NEC 3D structures
covalently binding warhead compounds
Online Access:https://www.mdpi.com/2073-4409/12/8/1162

Internet

https://www.mdpi.com/2073-4409/12/8/1162

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