MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia

MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia

Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with increases in QTc interval, which predispose patients to ventricular cardiac arrhythmias. The mechanisms invol...

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Bibliographic Details
Main Authors: Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemysław B. Radwański, Douglas H. Sweet, Jörg König, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
dofetilide
organic cation transporters
arrhythmia
PBPK modeling
Online Access:https://www.mdpi.com/1422-0067/23/15/8607

Internet

https://www.mdpi.com/1422-0067/23/15/8607

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