Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds

Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds

Bispecific antibodies (bsAbs) are antibodies with two binding sites directed at different antigens, enabling therapeutic strategies not achievable with conventional monoclonal antibodies (mAbs). Since bispecific antibodies are regarded as promising therapeutic agents, many different bispecific desig...

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Bibliographic Details
Main Authors: Lilach Vaks, Dana Litvak-Greenfeld, Stav Dror, LeeRon Shefet-Carasso, Galia Matatov, Limor Nahary, Shiran Shapira, Rahely Hakim, Iris Alroy, Itai Benhar
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Antibodies
Subjects:
Complementarity-determining region
Disulfide-stabilized Fv fragment
Knobs-into-holes
Monoclonal antibody
Streptavidin
Vascular endothelial growth factor
Online Access:http://www.mdpi.com/2073-4468/7/3/27

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http://www.mdpi.com/2073-4468/7/3/27

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