Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells

Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells

The Wnt/β-catenin, EGFR, and PI3K pathways frequently undergo upregulation in head and neck squamous carcinoma (HNSCC) cells. Moreover, the Wnt/β-catenin pathway together with Hedgehog (Hh) signaling regulate the activity of cancer stem cells (CSCs). The aim of this study was to investigate the effe...

Full description

Bibliographic Details
Main Authors: Robert Kleszcz, Mikołaj Frąckowiak, Dawid Dorna, Jarosław Paluszczak
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
Wnt pathway
hedgehog pathway
β-catenin
PRI-724
vismodegib
erlotinib
Online Access:https://www.mdpi.com/1422-0067/24/13/10448

Internet

https://www.mdpi.com/1422-0067/24/13/10448

Similar Items