New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model

New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model

Alzheimer’s disease (AD) is a neurodegenerative disease associated with memory impairment and other central nervous system (CNS) symptoms. Two myrtenal–adamantane conjugates (MACs) showed excellent CNS potential against Alzheimer’s models. Adamantane is a common pharmacophore for drug design, and my...

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Bibliographic Details
Main Authors: Stela Dragomanova, Maria Lazarova, Aldar Munkuev, Evgeniy Suslov, Konstantin Volcho, Nariman Salakhutdinov, Amina Bibi, Jóhannes Reynisson, Elina Tzvetanova, Albena Alexandrova, Almira Georgieva, Diamara Uzunova, Miroslava Stefanova, Reni Kalfin, Lyubka Tancheva
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
neuroprotection
experimental dementia
myrtenal–adamantane conjugates
acetylcholinesterase
monoamines
memory
Online Access:https://www.mdpi.com/1420-3049/27/17/5456

Internet

https://www.mdpi.com/1420-3049/27/17/5456

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