Rickettsia rickettsii virulence determinants RARP2 and RapL mitigate IFN-β signaling in primary human dermal microvascular endothelial cells

Rickettsia rickettsii virulence determinants RARP2 and RapL mitigate IFN-β signaling in primary human dermal microvascular endothelial cells

ABSTRACTWe compared the growth characteristics of a virulent Rickettsia rickettsii strain (Sheila Smith) to an attenuated R. rickettsii stain (Iowa) and a non-pathogenic species (R. montanensis) in primary human dermal microvascular endothelial cells (HDMEC). All replicated in Vero cells, however, o...

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Bibliographic Details
Main Authors: Liam Fitzsimmons, DeAnna Bublitz, Tina Clark, Ted Hackstadt
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
Rickettsia
innate immunity
virulence
interferon-beta
primary cells
Online Access:https://journals.asm.org/doi/10.1128/mbio.03450-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03450-23

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