Safety, tolerability and toxicokinetics of the novel mitochondrial drug SUL-138 administered orally to rat and minipig

Safety, tolerability and toxicokinetics of the novel mitochondrial drug SUL-138 administered orally to rat and minipig

Noncommunicable Chronic Diseases (NCD) are a socioeconomic burden and considered one of the major health challenges for coming decades. Mitochondrial dysfunction has been implicated mechanistically in their pathophysiology. Therefore, targeting mitochondria holds great promise to improve clinical ou...

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Bibliographic Details
Main Authors: Daniël H. Swart, Martin de Haan, Jasper Stevens, Rob H. Henning, Sovan Adel, Adrianus C. van der Graaf, Nadir Ulu, Daan J. Touw, Guido Krenning
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Toxicology Reports
Subjects:
Noncommunicable diseases
6-chromanols
Drug development
Metabolism
NOAEL
Preclinical toxicology
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750024000337

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http://www.sciencedirect.com/science/article/pii/S2214750024000337

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