Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism

Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism

Abstract Background The PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated phospho-AKT also translocates to mitochondria in the myocardium. Mouse models of diabetes exhibit impaired mitochondrial AKT signaling but the im...

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Bibliographic Details
Main Authors: Yu-Han Chen, Albert P. Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C. Jordan, Kenneth P. Roos, Grant R. MacGregor, Qin Yang, Robert A. Edwards, Junfeng Li, Ping H. Wang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cardiovascular Diabetology
Subjects:
Mitochondrial AKT
Heart failure
ATP synthase
Mitochondria dysfunction
Diabetic cardiomyopathy
Fatty liver
Online Access:https://doi.org/10.1186/s12933-023-02020-1

Internet

https://doi.org/10.1186/s12933-023-02020-1

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