Pyroptosis executor gasdermin D plays a key role in scleroderma and bleomycin-induced skin fibrosis

Pyroptosis executor gasdermin D plays a key role in scleroderma and bleomycin-induced skin fibrosis

Abstract The NLRP3 inflammasome and IL-1β are essential for scleroderma pathogenesis. Nevertheless, the role of pyroptosis executor gasdermin D(GSDMD), which is a downstream molecule of NLRP3 and is required for IL-1β release in some situations, has not yet been well elucidated in scleroderma. Here,...

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Bibliographic Details
Main Authors: Huan Yang, Yanqiang Shi, Huiting Liu, Feiyan Lin, Biying Qiu, Qinglan Feng, Yu Wang, Bin Yang
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00970-1

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https://doi.org/10.1038/s41420-022-00970-1

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