An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way: A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein

An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way: A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein

The characterization of modifications of microbial proteins is of primary importance to dissect pathogen lifecycle mechanisms and could be useful in identifying therapeutic targets. Attempts to solve this issue yielded only partial and non-exhaustive results. We developed a multidisciplinary approac...

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Bibliographic Details
Main Authors: Sergio Strizzi, Letizia Bernardo, Pasqualina D’Ursi, Chiara Urbinati, Andrea Bianco, Fiona Limanaqi, Andrea Manconi, Maria Milanesi, Alberto Macchi, Dario Di Silvestre, Adalberto Cavalleri, Giovanni Pareschi, Marco Rusnati, Mario Clerici, PierLuigi Mauri, Mara Biasin
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Pharmacological Research
Subjects:
UV light
Spike protein
Proteomics
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823002189

Internet

http://www.sciencedirect.com/science/article/pii/S1043661823002189

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