Effect of Pterostilbene, a Natural Derivative of Resveratrol, in the Treatment of Colorectal Cancer through Top1/Tdp1-Mediated DNA Repair Pathway

Effect of Pterostilbene, a Natural Derivative of Resveratrol, in the Treatment of Colorectal Cancer through Top1/Tdp1-Mediated DNA Repair Pathway

Topoisomerase 1 (Top1) inhibitor is an effective anticancer drug, but several factors limit its clinical application such as drug inactivation, tyrosyl-DNA phosphodiesterase 1 (Tdp1)-mediated tumor drug resistance, and its toxicity. Our previous study identified pterostilbene (PTE) and resveratrol (...

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Bibliographic Details
Main Authors: Yutian Zhang, Ying Li, Changcheng Sun, Xiang Chen, Luyao Han, Tingqiang Wang, Jinfeng Liu, Xijing Chen, Di Zhao
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
pterostilbene
resveratrol
topoisomerase 1
tyrosyl-DNA phosphodiesterase 1
colorectal cancer
Online Access:https://www.mdpi.com/2072-6694/13/16/4002

Internet

https://www.mdpi.com/2072-6694/13/16/4002

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