Microglia have limited influence on early prion pathogenesis, clearance, or replication.

Microglia have limited influence on early prion pathogenesis, clearance, or replication.

Microglia (MG) are critical to host defense during prion infection, but the mechanism(s) of this neuroprotection are poorly understood. To better examine the influence of MG during prion infection, we reduced MG in the brains of C57BL/10 mice using PLX5622 and assessed prion clearance and replicatio...

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Bibliographic Details
Main Authors: Brent Race, Katie Williams, Chase Baune, James F Striebel, Dan Long, Tina Thomas, Lori Lubke, Bruce Chesebro, James A Carroll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0276850

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https://doi.org/10.1371/journal.pone.0276850

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