The impact of missense mutation in PIGA associated to paroxysmal nocturnal hemoglobinuria and multiple congenital anomalies-hypotonia-seizures syndrome 2: A computational study

The impact of missense mutation in PIGA associated to paroxysmal nocturnal hemoglobinuria and multiple congenital anomalies-hypotonia-seizures syndrome 2: A computational study

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The disease is caused by the deficiency of two glycosylphosphatidylinositols (GPI)-anchored proteins (CD55 and CD59) in the hemopoietic st...

Full description

Bibliographic Details
Main Authors: Ashish Kumar Agrahari, Enrico Pieroni, Gianluca Gatto, Amit Kumar
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Heliyon
Subjects:
Biophysics
Condensed matter physics
Computational chemistry
Theoretical chemistry
Bioinformatics
Missense mutations
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019363698

Internet

http://www.sciencedirect.com/science/article/pii/S2405844019363698

Similar Items