Effects of polyphenolic maqui (Aristotelia chilensis) extract on the inhibition of NLRP3 inflammasome and activation of mast cells in a mouse model of Crohn’s disease-like colitis

Effects of polyphenolic maqui (Aristotelia chilensis) extract on the inhibition of NLRP3 inflammasome and activation of mast cells in a mouse model of Crohn’s disease-like colitis

IntroductionCrohn’s disease (CD) involves activation of mast cells (MC) and NF-кB in parallel with the PPAR-α/NLRP3 inflammasome/IL-1β pathway in the inflamed colon. Whether polyphenols from maqui (Aristotelia chilensis) represent a natural alternative treatment for CD is unclear. Therefore, we used...

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Bibliographic Details
Main Authors: Tamara Ortiz-Cerda, Federico Argüelles-Arias, Laura Macías-García, Victoria Vázquez-Román, Gladys Tapia, Kangzhe Xie, María Desirée García-García, Manuel Merinero, Josefa-María García-Montes, Ana Alcudia, Paul K. Witting, Manuel De-Miguel
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
Crohn’s disease
polyphenols
anthocyanins
maqui
mast cells
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229767/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229767/full

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