Synthesis of new thiazolyl-thienyl and thiazolyl-thiadiazolyl ketones: Molecular modelling and docking studies as antimicrobial agents

Synthesis of new thiazolyl-thienyl and thiazolyl-thiadiazolyl ketones: Molecular modelling and docking studies as antimicrobial agents

Eight thiazolyl-thienyl and thiazolyl-thiadiazolyl ketones 5a-d and 6a-d were synthesized based on the reaction of 5-(2-bromoacetyl)-4-methyl-2-(methylamino)thiazole (2) and/or N-(4-chlorophenyl)-2-(4-methyl-2-(methylamino)thiazol-5-yl)-2-oxoacetohydrazonoyl bromide (3) with four various thiocarbamo...

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Bibliographic Details
Main Authors: Haifa Alharbi, Omar Alsalmi, Adel I. Alalawy, Ahmad Fawzi Qarah, Abdulrahman A. Alsimaree, Alaa M. Alqahtani, Amerah Alsoliemy, Nashwa M. El-Metwaly
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Saudi Chemical Society
Subjects:
Hydrazonoyl bromide
Thiazolyl-thienyl ketones
DFT approach
Antibacterial
PDB:3VSL
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610323002041

Internet

http://www.sciencedirect.com/science/article/pii/S1319610323002041

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