Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

Abstract Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota, along with clinical evidence of prebiot...

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Main Authors: Chee Kin Then, Salome Paillas, Aliu Moomin, Mariya D. Misheva, Rachel A. Moir, Susan M. Hay, David Bremner, Kristine S. Roberts (nee Nellany), Ellen E. Smith, Zeynab Heidari, Daniel Sescu, Xuedan Wang, Alejandro Suárez-Bonnet, Nadine Hay, Sarah L. Murdoch, Ryoichi Saito, Elaina S. R. Collie-Duguid, Shirley Richardson, Simon L. Priestnall, Joan M. Wilson, Mahalakshmi Gurumurthy, Justine S. Royle, Leslie M. Samuel, George Ramsay, Katherine A. Vallis, Kevin R. Foster, James S. O. McCullagh, Anne E. Kiltie
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Microbiome
Subjects:
Radiotherapy
Dietary fibre
Gut microbiota
Short-chain fatty acids
Isoferulic acid
Cancer
Online Access:https://doi.org/10.1186/s40168-024-01804-1

Internet

https://doi.org/10.1186/s40168-024-01804-1

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