Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging

Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging

BACKGROUND Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology — promote cortical excitability and neuronal network dysfunction. In healthy humans, misfolded...

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Bibliographic Details
Main Authors: Maxime Van Egroo, Daphne Chylinski, Justinas Narbutas, Gabriel Besson, Vincenzo Muto, Christina Schmidt, Davide Marzoli, Paolo Cardone, Nora Vandeleene, Martin Grignard, André Luxen, Eric Salmon, Christian Lambert, Christine Bastin, Fabienne Collette, Christophe Phillips, Pierre Maquet, Mohamed Ali Bahri, Evelyne Balteau, Gilles Vandewalle
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-01-01
Series:JCI Insight
Subjects:
Aging
Neuroscience
Online Access:https://doi.org/10.1172/jci.insight.142514

Internet

https://doi.org/10.1172/jci.insight.142514

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