HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta.

HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta.

Hepatitis C Virus (HCV) is remarkably efficient at establishing persistent infection and is associated with the development of chronic liver disease. Impaired T cell responses facilitate and maintain persistent HCV infection. Importantly, CD4(+) regulatory T cells (Tregs) act by dampening antiviral...

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Bibliographic Details
Main Authors: Caroline H T Hall, Rachel Kassel, Robert S Tacke, Young S Hahn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2921368?pdf=render

Internet

http://europepmc.org/articles/PMC2921368?pdf=render

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