Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms

Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms

Summary: Cisplatin (CDDP) has been a highly successful anticancer drug in cancer therapy; however, its further application suffers severe nephrotoxicity. Herein, we identify bismuth tetraphenylporphyrinate [Bi(TPP)] as a potent protective agent against CDDP-induced nephrotoxicity. Bi(TPP) attenuates...

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Bibliographic Details
Main Authors: Runming Wang, Suyu Wang, Shing Chan, Yuchuan Wang, Yufeng Zhang, Zhong Zuo, Godfrey Chi-Fung Chan, Hongyan Li, Hongzhe Sun
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Inorganic Chemistry
Organometallic Chemistry
Medical Biochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030239X

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http://www.sciencedirect.com/science/article/pii/S258900422030239X

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