Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of <i>RAD51A</i> Pre-mRNA in Normal Human CD4<sup>+</sup> T Lymphocytes

Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of <i>RAD51A</i> Pre-mRNA in Normal Human CD4<sup>+</sup> T Lymphocytes

Physiological polyamines are ubiquitous polycations with pleiotropic biochemical activities, including regulation of gene expression and cell proliferation as well as modulation of cell signaling. They can also decrease DNA damage and promote cell survival. In the present study, we demonstrated that...

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Bibliographic Details
Main Authors: Yulia A. Gladilina, Lylia Bey, Abdullah Hilal, Ekaterina V. Neborak, Varvara G. Blinova, Dmitry D. Zhdanov
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
polyamines
alternative splicing
DNA damage
cytoprotection
apoptosis
Online Access:https://www.mdpi.com/1422-0067/23/3/1863

Internet

https://www.mdpi.com/1422-0067/23/3/1863

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