De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants

De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants

Abstract Clostridioides difficile toxin B (TcdB) is the key virulence factor accounting for C. difficile infection-associated symptoms. Effectively neutralizing different TcdB variants with a universal solution poses a significant challenge. Here we present the de novo design and characterization of...

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Bibliographic Details
Main Authors: Xinchen Lv, Yuanyuan Zhang, Ke Sun, Qi Yang, Jianhua Luo, Liang Tao, Peilong Lu
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52582-1

Internet

https://doi.org/10.1038/s41467-024-52582-1

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