3-Heptylidene-4,6-Dimethoxy-3<i>H</i>-Isobenzofuran-1-One Is Genotoxic, Increases the Frequency of Cell Death, and Potentiates the Effects of Cyclophosphamide and Cisplatin

3-Heptylidene-4,6-Dimethoxy-3<i>H</i>-Isobenzofuran-1-One Is Genotoxic, Increases the Frequency of Cell Death, and Potentiates the Effects of Cyclophosphamide and Cisplatin

3-heptylidene-4,6-dimethoxy-3<i>H</i>-isobenzofuran-1-one (Phthalide <b>1</b>) is the precursor of three resorcinol lipids that have been described as potential chemotherapeutic agents and capable of potentiating the effects of cyclophosphamide. In this study, we evaluated th...

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Bibliographic Details
Main Authors: Silvia Cordeiro das Neves, Flavio Henrique de Araújo, Willian Ayala Correa, Allana Cristina Faustino Martins, Henrique Rodrigues Scherer Coelho, Marcelo Luiz Brandão Vilela, Valter Aragão do Nascimento, Candida Aparecida Leite Kassuya, Dênis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira, Roberto da Silva Gomes
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
Phthalide <b>1</b>
in vivo
toxicology
chromosomal damage
Online Access:https://www.mdpi.com/1420-3049/28/3/1044

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https://www.mdpi.com/1420-3049/28/3/1044

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