Pragmatic physiologically-based pharmacokinetic modeling to support clinical implementation of optimized gentamicin dosing in term neonates and infants: proof-of-concept

Pragmatic physiologically-based pharmacokinetic modeling to support clinical implementation of optimized gentamicin dosing in term neonates and infants: proof-of-concept

IntroductionModeling and simulation can support dosing recommendations for clinical practice, but a simple framework is missing. In this proof-of-concept study, we aimed to develop neonatal and infant gentamicin dosing guidelines, supported by a pragmatic physiologically-based pharmacokinetic (PBPK)...

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Bibliographic Details
Main Authors: Marika A. de Hoop-Sommen, Joyce E. M. van der Heijden, Jolien J. M. Freriksen, Rick Greupink, Saskia N. de Wildt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pediatrics
Subjects:
term neonate
infant
PBPK
model-informed dose
gentamicin
pediatric pharmacology
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2023.1288376/full

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https://www.frontiersin.org/articles/10.3389/fped.2023.1288376/full

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