Structure-Based Design, Synthesis, and Biological Evaluation of the Cage–Amide Derived Orthopox Virus Replication Inhibitors

Structure-Based Design, Synthesis, and Biological Evaluation of the Cage–Amide Derived Orthopox Virus Replication Inhibitors

Despite the fact that the variola virus is considered eradicated, the search for new small molecules with activity against orthopoxviruses remains an important task, especially in the context of recent outbreaks of monkeypox. As a result of this work, a number of amides of benzoic acids containing a...

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Bibliographic Details
Main Authors: Evgenii S. Mozhaitsev, Evgeniy V. Suslov, Daria A. Rastrepaeva, Olga I. Yarovaya, Sophia S. Borisevich, Edward M. Khamitov, Dmitry S. Kolybalov, Sergey G. Arkhipov, Nikolai I. Bormotov, Larisa N. Shishkina, Olga A. Serova, Roman V. Brunilin, Andrey A. Vernigora, Maxim B. Nawrozkij, Alexander P. Agafonov, Rinat A. Maksyutov, Konstantin P. Volcho, Nariman F. Salakhutdinov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
adamantane
amides
antipox activity
p37
Online Access:https://www.mdpi.com/1999-4915/15/1/29

Internet

https://www.mdpi.com/1999-4915/15/1/29

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