Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway

Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway

Objective Pancreatic cancer is an incurable malignant disease with extremely poor prognosis and a complex tumor microenvironment. We sought to characterize the role of Annexin A1 (ANXA1) in pancreatic cancer, including its ability to promote efferocytosis and antitumor immune responses.Methods The t...

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Bibliographic Details
Main Authors: Heguang Huang, Yuwei Wu, Yu Pan, Zelin Hou, Fengchun Lu, Jiajing Lin, Linjin Chen, Haizong Fang, Linlin Chen, Shihan Zhang
Format: Article
Language:English
Published: BMJ Publishing Group 2024-09-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/9/e009318.full

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https://jitc.bmj.com/content/12/9/e009318.full

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