Robustness assessment of cation-exchange chromatography with in-silico peak deconvolution in monoclonal antibody purification
An in-silico tool with peak deconvolution for preparative chromatograms was developed for assessing the robustness for peak fluctuations depending on loaded sample quality. The peak positions of high-molecular-weight species (HMWS), target monoclonal antibody (Main), and low-molecular-weight species...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
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| Series: | Journal of Chromatography Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391722000305 |