Robustness assessment of cation-exchange chromatography with in-silico peak deconvolution in monoclonal antibody purification

Robustness assessment of cation-exchange chromatography with in-silico peak deconvolution in monoclonal antibody purification

An in-silico tool with peak deconvolution for preparative chromatograms was developed for assessing the robustness for peak fluctuations depending on loaded sample quality. The peak positions of high-molecular-weight species (HMWS), target monoclonal antibody (Main), and low-molecular-weight species...

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Bibliographic Details
Main Authors: Ryunosuke Kitamura, Takaki Aiso, Kosaku Kawatsu, Yumiko Masuda, Takefumi Kawabe, Koichi Nonaka, Etsuo Yonemochi
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Chromatography Open
Subjects:
Peak fitting
Mathematical model
Second derivative
Online Access:http://www.sciencedirect.com/science/article/pii/S2772391722000305

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