RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure.

RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure.

The ubiquitin ligase RAD18 is involved in post replication repair pathways via its recruitment to stalled replication forks, and its role in the ubiquitylation of proliferating cell nuclear antigen (PCNA). Recently, it has been reported that RAD18 is also recruited to DNA double strand break (DSB) s...

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Bibliographic Details
Main Authors: Megumi Sasatani, Yanbin Xu, Hidehiko Kawai, Lili Cao, Satoshi Tateishi, Tsutomu Shimura, Jianxiang Li, Daisuke Iizuka, Asao Noda, Kanya Hamasaki, Yoichiro Kusunoki, Kenji Kamiya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4326275?pdf=render

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http://europepmc.org/articles/PMC4326275?pdf=render

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