Uridylation of the histone mRNA stem-loop weakens binding interactions with SLBP while maintaining interactions with 3’hExo

Uridylation of the histone mRNA stem-loop weakens binding interactions with SLBP while maintaining interactions with 3’hExo

Histone mRNA degradation is controlled by the unique 3’ stem-loop of histone mRNA and the stem-loop binding protein (SLBP). As part of this process, the 3’ stem-loop is trimmed by the histone-specific 3’ exonuclease (3’hExo) and uridylated by the terminal uridylyl transferase 7 (TUT7), creating part...

Full description

Bibliographic Details
Main Authors: Morgan Shine, Sarah E. Harris, Kendy A. Pellegrene, Adam H. Kensinger, Mihaela Rita Mihailescu, Jeffrey D. Evanseck, Patrick E. Lackey
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:RNA Biology
Subjects:
histone mrna
rna degradation
rna binding proteins
molecular dynamics
Online Access:http://dx.doi.org/10.1080/15476286.2023.2171760

Internet

http://dx.doi.org/10.1080/15476286.2023.2171760

Similar Items