ASIC1a senses lactate uptake to regulate metabolism in neurons

ASIC1a senses lactate uptake to regulate metabolism in neurons

Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca2+, Mg2+ and Zn2+, that block the channe...

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Bibliographic Details
Main Authors: Ivana Savic Azoulay, Xin Qi, Maya Rozenfeld, Fan Liu, Qin Hu, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Michael X. Zhu, Tian-Le Xu, Israel Sekler
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
ASIC1a
Cytosolic Na+ signaling
Cytosolic Ca2+ signaling
Mitochondrial Na+ signaling
Mitochondrial Ca2+ signaling
NCLX
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000258

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http://www.sciencedirect.com/science/article/pii/S2213231722000258

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