ASIC1a senses lactate uptake to regulate metabolism in neurons

ASIC1a senses lactate uptake to regulate metabolism in neurons

Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca2+, Mg2+ and Zn2+, that block the channe...

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Bibliographic Details
Main Authors:	Ivana Savic Azoulay, Xin Qi, Maya Rozenfeld, Fan Liu, Qin Hu, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Michael X. Zhu, Tian-Le Xu, Israel Sekler
Format:	Article
Language:	English
Published:	Elsevier 2022-05-01
Series:	Redox Biology
Subjects:	ASIC1a Cytosolic Na+ signaling Cytosolic Ca2+ signaling Mitochondrial Na+ signaling Mitochondrial Ca2+ signaling NCLX
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231722000258

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